Adaferin Gel is a naphthoic acid derivative with retinoid-like pharmacological properties. It possesses modulatory and anti-inflammatory effects. Adaferin Gel can be used as a single agent in mild acne or in combination with antimicrobial agents in inflammatory acne and has proved to be effective as maintenance treatment. As compared to other retinoids, Adapalene has a rapid onset of action and a particular tolerability profile. The drug is, therefore, assured of a role in the first line treatment of acne vulgaris.
Adaferin Gel is a retinoid product, indicated for the topical treatment of acne vulgaris in patients twelve years of age and older. Acne vulgaris is a condition in which skin has whiteheads, blackheads, and pimples.
Adaferin Gel should be applied once daily to affected areas of your skin after washing in the evening before retiring. During the initial days of the treatment, an apparent exacerbation of acne may occur. It can be due to the action of the medicine on previously unseen lesions and should not be considered as a reason to stop the treatment.
Wash the area where Adaferin Gel will be applied with a non-medicated soap and pat dry. Avoid application of the areas of skin around lips, eyes, and mouth. Squeeze a small amount onto your fingertips and spread a thin layer of gel over the entire area of the face and other affected areas of your skin. A mild temporary sensation of warmth and slight stinging may occur shortly after the application of the gel. You may use moisturizers for the relief of irritation or dry skin. Patients should be instructed to minimize sun exposure.
Adaferin Gel is intended for topical use only. If the medicine is applied excessively, no more rapid or better results will be attained, and marked peeling, redness, or skin discomfort may occur. Adaferin Gel is contraindicated in patients who have shown hypersensitivity to the drug or any of the drug’s components.
Exposure to sunlight should be minimized during the treatment with Adaferin gel. Patients with inherent sensitivity to the sun and those who normally experience high levels of skin exposure should be warned to exercise caution. Use of sunscreen lotions and protective clothing is recommended when exposure cannot be avoided.
Certain cutaneous reactions such as dryness, scaling, burning, erythema may occur. These reactions are likely to occur during the first two to four weeks of treatment, are mostly mild to moderate, and usually reduces with continued use of the medicine. Depending on the severity of these adverse effects, patients should be instructed to use an oil-free moisturizer or reduce the frequency of application of Adaferin Gel. If patients use cosmetics, these should be non-astringent and non-comedogenic.
The gel should not be applied to abrasions, cuts, or sunburned skin.
Reactions characterized by symptoms such as facial edema, lip swelling, pruritis, eyelid edema may also occur during the treatment. A patient should stop using Adaferin Gel and consult a doctor if experiencing allergic reactions.
Some side effects such as dryness, peeling, erythema, burning, and pruritis have been reported. These are most commonly seen during the first month of treatment and decrease in frequency thereafter. Always talk to your doctor if the side effects get worse.
As Adaferin Gel has the potential to induce irritation in some patients, concomitant use of other topical agents (medicated soaps and cleansers, cosmetics that have a strong drying effect, and products that contain resorcinol, salicylic acid, and sulfur) should be used with caution.
Adaferin Gel comprises of an active ingredient called Adapalene that adheres to specific retinoic acid and nuclear receptors, but does not adhere to the cytosolic receptor protein. According to pharmacological profile, the drug is a modulator of cellular differentiation, inflammatory process, and keratinization. However, the importance of these findings with regard to the mode of action of Adapalene for the treatment of acne vulgaris is unknown.
Adaferin Gel should be stored in a safe place that is away from heat and moisture. Do not refrigerate. Keep the drug out of the reach of children and pets. Do not keep the medicine out in the open.
